結(jié)直腸癌干細(xì)胞表面標(biāo)志物和信號(hào)通路研究進(jìn)展 B

既往臨床實(shí)驗(yàn)證實(shí)棉酚可以用 來(lái)治療前列腺癌等多種腫瘤，通過(guò)SRP和NMR實(shí) 驗(yàn)發(fā)現(xiàn)，棉酚( gossypol)可與Msil RBD1相結(jié)合，與 Bcl-2家族的結(jié)合相比有著更高的親和力，增加了Numb和APC的表達(dá)，抑制Wnt和Notch通路，起到治療結(jié)直腸癌的作用[17]。沉默Msil的結(jié)直腸癌細(xì)胞克隆形成能力下降、腫瘤生長(zhǎng)速度減慢、細(xì)胞周期停滯在G7/M期，給予沉默Msil的結(jié)腸癌HCT116細(xì)胞12 Gy放射線照射，細(xì)胞凋亡數(shù)增加了4倍，表明沉默Msil能使放療敏感性增加，另有研究證實(shí)β -catenin對(duì)于放療具有抗性，而Msil可 能通過(guò)促進(jìn)B -catenin的核內(nèi)聚，增加了結(jié)直腸癌放療的不敏感性[19]。

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